the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Get the most important science stories of the day, free in your inbox. “Even if lose my job some time, I can maybe put wallpaper up as a career.”. “Yoshi's country, of course.”, You can also search for this author in His research was halted by a moratorium issued from the US government in 2014. Still, running two labs gives Kawaoka the best of both worlds. [2] For now, no known vaccine has been found. U.S. scientists have devised a technique that might allow researchers to study the deadly Ebola virus in other than a few highly specialized laboratories. Profile: Yoshihiro Kawaoka. A genetic analysis of a bird flu strain responsible for at least nine human deaths in China suggests it could evolve to adapt to human cells, researchers say. Even in a constant state of jetlag, Yoshihiro Kawaoka is a fiercely productive flu researcher. Yoshihiro Kawaoka is a leading scientist in the field of influenza and other infectious diseases. Genetic analysis shows new bird flu strain could affect humans. I can match the pattern,” he says. If people make comments, I don't say a word. Scientists have found new evidence that the H7N9 bird flu, currently confined to China, has the potential for a widespread outbreak. Not surprisingly, Japanese would also be the language of his choice in any country he owns. Kawaoka promises to retire at 65 and stay home doing nothing, perhaps only listening to music and reading novels by the Japanese author Mangetsu Hanamura. A U.S. medical team has found a way of spotting genes that help spread the bird flu, the subject of global concern as a potential pandemic threat. https://doi.org/10.1038/nm0506-489, Nature Medicine Last year, on the twenty-fifth anniversary of his marriage, Kawaoka found himself once again on a plane to Japan. “But it doesn't matter whether I do this work in Japan or the US or wherever. YOSHIHIRO KAWAOKA. At first, the virus was only mildly pathogenic. and JavaScript. “We're all amazed at how he can physically manage to function so well in two different time zones,” says Krisna Wells, who has worked with Kawaoka since 1987. He doesn't eat much, sleeps even less and is perpetually jetlagged. He holds a professorship in virology in the Department of Pathobiological Sciences at the University of Wisconsin-Madison, … A compound tested in mice has proved safer and more effective against H5N1 bird flu than the popular antiviral Tamiflu, scientists in Wisconsin said. After his mentor in Hokkaido introduced him to Robert Webster, already a leader in influenza work, Kawaoka went to humid, mosquito-infested Memphis—and stayed there for 14 years. “[Kawaoka] has since lost that formality somewhat.”, One year, Webster's wife taught Kawaoka to wallpaper the rooms. Kawaoka engineered a method to generate entire viruses from genetic sequences, a technology that's now used to make flu vaccines. Perhaps, Kawaoka says laughing, the country would be populated only with women. Even as a postdoc at St. Jude Children's Research Hospital in Memphis, Tennessee, Kawaoka was in the lab when the cleaning lady arrived in the early evening, would go home to sleep at some point and be back again, ready to start the next day, before she left. Sensitive about his English speaking skills—regularly criticized by his students at the University of Wisconsin—he says he would probably want to die in Japan, where he wouldn't have to worry about making sense to the doctors. Yoshihiro Kawaoka (河岡 義裕; born 14 November 1955) is a Japanese virologist at University of Tokyo. The study led by Yoshihiro Kawaoka of the University of Wisconsin confirms it was the virulence a, Bitcoin surges past $15,700 to highest value since January 2018, U.S. reports more than 120,000 new COVID-19 cases, Time capsule from the North Pole washes up in Ireland two years later, Oregon votes to legalize psychedelic mushrooms in therapy settings, Man caught walking stuffed dog after curfew in Czech Republic. Thank you for visiting nature.com. If Yoshihiro Kawaoka owned a country, its citizens would be well protected from a bird flu pandemic. “If people make comments, I don't say a word. “[Speaking] as a mentor, he was the best student ever. Webster took Kawaoka to the early-morning poultry markets in New York City to sample the birds that were the source of the Pennsylvania virus. Yoshihiro Kawaoka (河岡 義裕, Kawaoka Yoshihiro, born November 14, 1955) is a virologist specializing in the study of the influenza and Ebola viruses. “Often I hear from Japanese that we, meaning Japanese, should do the work that sends a message to the world,” says Kawaoka. Following the West African Ebola virus epidemic of 2014, Kawaoka began development of an Ebola vaccine working in close coordination with Dr. Alhaji N'jai a toxicologist at the University of Wisconsin–Madison and his non-profit organization Project 1808, Inc.[1], Kawaoka reinvented a new virus based on H5N1, which he revealed to the public in 2011. However in 2019 he was allowed to resume the research. Webster recalls that when Kawaoka and his family first arrived in the US, they were polite and proper, as most Japanese are. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. Follow Following. He has published paper after high-profile paper describing what makes certain flu viruses lethal and how they acquire resistance to available drugs. But they were embarrassed out of their minds,” Webster recalls. You can help Wikiquote by expanding it. But soon after he began working in the field, “Yoshi really came on the scene with a bang,” recalls Tom Geisbert, chair of viral pathology at the US Army Medical Research Institute of Infectious Diseases in Fort Detrick, Maryland. He was brilliant,” Webster says. ISSN 1546-170X (online). When the researchers compared the April and October strains, they found that the milder strain had become more pathogenic after just a single mutation in the hemagglutinin gene (Virology 149, 165–173; 1986). That work, along with data from an outbreak in Mexico in 1993, established the concept that all highly pathogenic viruses are derived from nonpathogenic strains. Full-sized labs at each institution churn out top-notch publications, 27 in 2005 alone. Although the new (COVID-19) coronavirus is related to the virus that causes SARS, so far (as of 20 January 2020) it lacks the transmissibility of SARS. [5], Members of the United States National Academy of Sciences, "Ebola virus vp40-induced particle formation and association with the lipid bilayer", "Influenza A virus can undergo multiple cycles of replication without m2 ion channel activity", "Influenza Virus NS1 Protein Induces Apoptosis in Cultured Cells", "Plasminogen-binding activity of neuraminidase determines the pathogenicity of influenza A virus", "Amino Acids Responsible for the Absolute Sialidase Activity of the Influenza A Virus Neuraminidase: Relationship to Growth in Duck Intestine", "Ebora shukketsu netsu no seiatsu ni mukete : Wakuchin kaihatsu to shierareone de no kenkyu", "Scientists Brace for Media Storm Around Controversial Flu Studies", https://madison.com/wsj/news/local/health-med-fit/uw-madison-scientist-allowed-to-resume-controversial-flu-research/article_7778777c-75b8-5da0-beda-3232cb8083ef.html, "EXCLUSIVE: Controversial experiments that could make bird flu more risky poised to resume", "Sir Michael Stoker Prize & Lecture 2018", Robert Koch Award lecture: New possibilities in the fight against influenza, https://en.wikipedia.org/w/index.php?title=Yoshihiro_Kawaoka&oldid=958525863, Creative Commons Attribution-ShareAlike License, This page was last edited on 24 May 2020, at 08:44. In April 1983, four months before he arrived in the US, an H5N2 flu virus was sickening chickens in Pennsylvania. Since 1999, Kawaoka has juggled dual appointments at the University of Tokyo and the University of Wisconsin in Madison. volume 12, page489(2006)Cite this article. But in October that year, it suddenly began killing chickens in large numbers. Study: H1N1 flu more virulent than thought. “I watch the seams, you know, I can do it better. The latest study conducted by UW-Madison virologist Yoshihiro Kawaoka, a world authority on influenza, documented an early warning that flu viruses may be beginning to outwit highly effective drugs. He holds a professorship in virology in the Department of Pathobiological Sciences at the University of Wisconsin-Madison, USA, and at the University of Tokyo, Japan. Nat Med 12, 489 (2006). And Wisconsin allows those students to run experiments with recombinant DNA, which is under strict regulation in Japan. Kawaoka knows that closing borders is impractical and would at best only stall the pandemic. We've found that the influenza virus has a specific mechanism that permits it to package its genetic material. close breaking news. I don't care what other people think.”. His appointment at the University of Tokyo's prestigious Institute for Medical Sciences guarantees that his lab is always supplied with the best Japanese students. The finding was made by a group led by Professor Kawaoka Yoshihiro and Project Assistant Professor Ueki Hiroshi at the University of Tokyo's Institute of Medical Science. Cats can catch COVID-19, no evidence they pass it to humans. “Personally, I don't think he sleeps.”. PubMed Google Scholar, Japan's laws on recombinant DNA tie researchers' hands, http://www.nature.com/nature/focus/avianflu/index.html#nov, Mandavilli, A. “We were highly amused. “The immune response provided by live virus, that is going to be the one that really protects humans,” Kawaoka says. YOSHIHIRO KAWAOKA. “She doesn't care about me publishing high-profile papers. To keep up his dual appointment, he often travels to Tokyo, sometimes for just a day. You are using a browser version with limited support for CSS. Some people might fall ill from the vaccine strain, but far greater numbers would benefit. [3][4], Dan Brown mentioned the experiment in his novel Inferno. yoshihiro.kawaoka@wisc.edu Supported by a grant (HHSN272201400008C, to Dr. Kawaoka) from the Center for Research on Influenza Pathogenesis, fund- His wife, Yuko, whose father worked 9-to-5 shifts and came home for lunch, was less than thrilled. Copyright © 2020 United Press International, Inc. All Rights Reserved. Yoshihiro Kawaoka is a leading scientist in the field of influenza and other infectious diseases. What she wants is for me to stay home,” he says. Displaying 10 out of 1 results World. But the dual appointment also has its share of headaches. This scientist article is a stub. Ever the eager student, Kawaoka mastered the skill and now inspects the wallpaper in his hotel rooms. Wonder what he could accomplish with a little bit of sleep? Wonder what he could accomplish with a little bit of sleep? But when it comes to a vaccine, he knows of what he speaks. I don't care what other people think.”. How Kawaoka has the energy to do so much is a mystery. Perhaps then he would work a little less. Kawaoka began his career with a stint in veterinary school at frosty Hokkaido University, followed by graduate degrees in microbiology and bacteriology. Kawaoka became interested in Ebola after reading The Hot Zone, the only English novel he says he has ever read. He is only half-serious. A team of U.S. virologists says the H1N1 flu virus pathogen is more virulent than previously thought. Confronted with a pandemic, Kawaoka says he would close his country's borders and release a vaccine based on the live, but weakened, bird flu virus.

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